In 1925, Stellwagen decided to treat patients for gonorrheal arthritis by injecting Pregl's solution (a complex hypo-iodite preparation) directly into the prostate. The results obtained were so good that since then Stellwagen's method has been part of the routine treatment for gonorrheal arthritis in the Philadelphia General Hospital.
In view of the excellent cures obtained from the use of Pregl's solution in the wards for genito-urinary diseases in the Philadelphia General Hospital, it was suggested by Dr. Searle H. Lanyon that, if properly administered, it might be effective in the treatment for gonorrheal ophthalmia in adults. He, together with Dr. Emil Senger, had used it subconjunctivally in a case and had obtained favorable results. As a consequence, it was determined to try Pregl's solution in a series of unselected cases.
TECHNIC Some preliminary tests were made, and the following procedure was adopted : After thorough irrigation of the eye with
COWAN A. SUBCONJUNCTIVAL INJECTION OF PREGL'S SOLUTION IN GONORRHEAL OPHTHALMIA. Arch Ophthalmol. 1930;3(3):325–330. doi:10.1001/archopht.1930.00810050077007
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