The chief investigations on the crystalline lens fall into three general groups: (1) the chemical researches, (2) researches which concern themselves with the action of radiant energy on the lens and (3) immunologic researches.
The earliest chemical analyses of the crystalline lens are those of Laptschinsky1 in 1876. They were followed by the early fundamental researches of Morner in 1894,2 which were later confirmed by Jess3 with more accurate analyses. These authors first demonstrated that lens protein had two different crystallins, which they called alpha and beta crystallins ; and also an insoluble residue which they termed "albuminoid." Lens protein as a whole contains between 16 and 17 per cent nitrogen. The sulphur content varies from 0.5 to 1 per cent in alpha crystallin and from 0.1 to 0.3 per cent in beta crystallin. These alpha and beta crystallins contain the usual amino-acids in greater
WOODS AC. CHEMICAL AND IMMUNOLOGIC RESEARCHES ON LENS PROTEIN. Arch Ophthalmol. 1930;4(1):96–105. doi:10.1001/archopht.1930.00810090106010
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