The isolation of Bacterium granulosis, and with it the production of lesions of the eye reminiscent of trachoma in monkeys, which was announced by Noguchi in 1928,1 has presented a new method of approach to the etiology of trachoma. Several investigators, Finnoff and Thygeson,2 Tilden and Tyler,3 and Stefanova and Asarowa4 among others, have already reported the presence of Bacterium granulosis in material taken from patients with the disease. McCartney,5 on the other hand, using the Noguchi procedure, failed to isolate the organism from a series of cases of trachoma, and a recent communication from Morax6 also reveals inability to recover the microbe from a series of eleven cases.
Noguchi, and Finnoff and Thygeson, reported the slow development of folliculosis in monkeys following conjunctival inoculation with their strains of Bacterium granulosis. This proceeded to scarring in some of Noguchi's animals, with the infection spreading
KENDALL AI, GIFFORD SR. TRACHOMA AND AVITAMINOSIS. Arch Ophthalmol. 1930;4(3):322–325. doi:10.1001/archopht.1930.00810110024003
Customize your JAMA Network experience by selecting one or more topics from the list below.