When the fibrovascular sheath which normally surrounds the fetal lens until the seventh month fails to disappear in the central part of its anterior portion, the condition is known as persistent pupillary membrane. When the posterior portion remains, the anomaly is referred to as persistent posterior fibrovascular sheath.
The case presented is of interest for two reasons ; (1) faulty diagnosis, the eye having been removed for suspected glioma; (2) the congenital anomalies found are associated with definite inflammatory changes in the adjacent structures. Literature in proof of hereditary influence in the production of such congenital defects as colomboma of the iris, aniridia, cataract, ectopia lentis, etc., is not wanting, but possibly on account of the infrequency of occurrence, no such influence has been attributed to retained fibrovascular sheaths. M. T. MacKlin, in 1927, cited one interesting case in which the father had aniridia and his thirteen children all showed
LEECH VM. PERSISTENT POSTERIOR FIBROVASCULAR SHEATH OF THE LENS CAUSED BY FETAL IRITIS. Arch Ophthalmol. 1930;4(3):332–337. doi:10.1001/archopht.1930.00810110034005
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