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September 1930


Arch Ophthalmol. 1930;4(3):348-349. doi:10.1001/archopht.1930.00810110050008

The authors two years ago1 published a preliminary report of a comprehensive study of three cases of keratoconus in which, based on roentgenologic studies of the skulls, it was suggested that a careful examination of the calcium metabolism in such cases might lead to a clue concerning their etiology. Briefly, exhaustive clinical examination of the patients in the three original cases, careful search of the family histories and minute inquiry into the personal histories did not reveal any abnormality that might serve as a point of departure on which to build a logical theory as to etiology except that in all three cases the x-ray pictures of the skulls showed in more or less numerous areas apparent lack of calcification. The basal metabolism was also found to be low. With this in one case was found great softness of the teeth. The results of the historical and physical examinations

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