In 1921, the attention of the senior author was directed to the work of Guyer and E. A. Smith in the experimental production of eye defects and particularly to the anatomic nature of the anomalies obtained. At that time a gross and microscopic study of the defective eyes of Dr. Guyer's stock was undertaken, the results of which were presented in a paper before the convention of English-speaking ophthalmologic societies in London, July, 1925.1 No attempt was then made to analyze the results of Guyer and Smith, but the work was limited to a description of the lesions found. Briefly, this study showed that the defects obtained centered in the failure of the fetal ocular cleft to close or in its improper closure. The cleft remains open due to inhibition of growth of the developing optic vesicle or it is mechanically prevented from closing by ingrowth of mesodermal tissue.
DAVIS FA, SMITH HM. THE RÔLE OF LENS ANTIGEN AND UVEAL PIGMENT IN THE PRODUCTION OF HEREDITARY ANOMALIES OF THE EYE. Arch Ophthalmol. 1930;4(5):672–690. doi:10.1001/archopht.1930.00810130062006
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