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Article
December 1930

OCULAR LESIONS OF RAT-BITE FEVER IN GUINEA-PIGS

Arch Ophthalmol. 1930;4(6):858-867. doi:10.1001/archopht.1930.00810140070004
Abstract

Although the ocular lesions of animals with rat-bite fever (Sodoku) have an intrinsic interest, meriting study and description, the superficial resemblance of the eyes of guinea-pigs in the late stages of the disease to the eyes of horses affected with the periodic ophthalmia known as "moon-blindness" prompted us to investigate in detail these lesions in guinea-pigs. Since the beginning of this work, personal communications from Dr. Alan C. Woods, summarizing his unpublished studies of "moon-blindness" in horses, indicate that periodic ophthalmia of horses has nothing in common etiologically and little in common pathologically with the conjunctivitis, keratitis, uveitis and final panophthalmitis that occur in guinea-pigs infected with Spirochaeta morsus-muris, the organism causing rat-bite fever. Some of the original confusion concerning the condition was due to the incomplete descriptions of the ocular lesions of rat-bite fever that have been published. In order to supply lacking information and

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