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March 1931

TWO PER CENT EPINEPHRINE SOLUTIONS AS SUBSTITUTES FOR LAEVOGLAUCOSAN

Arch Ophthalmol. 1931;5(3):350-353. doi:10.1001/archopht.1931.00820030034003
Abstract

Many are familiar with the properties of the synthetic levorotatory tartaric acid alkaloid derived from the suprarenal capsule, the so-called links or laevoglaucosan that was introduced by Hamburger in 1923. Used in 2 per cent solution and combined with methylamino-acetopyrocatechol in the same strength, it can be used by instillation and produces the following effects: (1) intense ischemia of the conjunctiva, with bloodless islets appearing in the cheek, lid and temple; (2) widening of the palpebral aperture ; (3) regular and wide dilatation of the pupil, and (4) a diminution in intra-ocular tension (sometimes preceded by an initial rise).

I have used laevoglaucosan in cases of glaucoma simplex for three years, and believe it to be a valuable adjuvant to miotics. It is not universally successful in reducing tension; some failures must be admitted.

Laevoglaucosan has the following drawbacks : ( 1 ) it is furnished in small ampules, each containing only a

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