The rosette denotes primarily a structure of characteristic appearance occurring typically in neuro-epithelioma (or neurocytoma) of the retina. The researches of Wintersteiner1 virtually established the neuro-epithelium of the retina as the basis for the new growth, and defined the rosette as a palisade arrangement of neuro-epithelium about the external limiting membrane as a lumen. While many still believe that glial cells and their processes,2 rather than nervous cells, furnish the material for the growth, Wintersteiner's conception of the rosette has remained almost universally accepted.
Rosettes in human eyes of other than pathologic significance have been found for the most part in fetuses from 5 to 8 months old or in infants. Seefelder3 was the first to observe small rosettes in two fetuses, between the ganglion and inner nuclear layers, at the border of the optic nerve and retina in one case, and at the entrance of
GOLDSTEIN I, WEXLER D. ROSETTE FORMATION IN THE EYES OF IRRADIATED HUMAN EMBRYOS. Arch Ophthalmol. 1931;5(4):591–600. doi:10.1001/archopht.1931.00820040087006
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