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Article
February 1932

AMBLYOPIA FROM ETHYLHYDROCUPREINE

Author Affiliations

OMAHA
From the Department of Ophthalmology, Creighton Medical College.

Arch Ophthalmol. 1932;7(2):285-293. doi:10.1001/archopht.1932.00820090125010
Abstract

Ethylhydrocupreine is the most recent of a series of quinine derivatives to be cited for its value in the treatment for pneumonia. That the drug is used quite extensively is shown by Cross1 who reported observations made in 126 cases of pneumonia in which it was employed as the principal medication. The present use of ethylhydrocupreine was first suggested by Mendel's2 publication in 1916. Here he stated that it was preferable to other alkaloids of quinine because its rate of absorption could be controlled. As ethylhydrocupreine is soluble in the hydrochloric acid of the stomach, his practice was to give 5 ounces (141.7 Gm.) of milk with each dose of the drug to lessen the concentration of the free hydrochloric acid in the gastric contents. This lengthened the time necessary to convert the base into the acid salt, and prevented its rapid absorption into the

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