It is generally accepted that the intra-ocular and spinal fluids are a dialysate of the blood, and also that the vitreous filtrate of animals and the spinal fluid of man are of similar composition; therefore, a study of the composition of the human spinal fluid may provide information concerning the chemical composition of human intra-ocular fluid, which obviously is not available for analysis. Analysis of the blood of both man and animals shows great constancy of the organic and inorganic constituents. The increase of the intra-ocular fluid is the most important factor in the causation of the symptoms of primary glaucoma. We believe, with others, that this increase of intra-ocular pressure has a physicochemical basis, although this hypothesis has not as yet been proved.
With a consideration of these facts, we started our present study. For the past seven years we have been engaged in the physicochemical study of
COHEN M, KILLIAN JA, HALPERN L. CHEMICAL COMPOSITION OF THE BLOOD AND SPINAL FLUID IN PRIMARY GLAUCOMACOMPARATIVE STUDIES. Arch Ophthalmol. 1932;8(1):39–49. doi:10.1001/archopht.1932.00820140047005