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October 1932


Author Affiliations

From the Carnegie Embryological Laboratory and the Wilmer Ophthalmological Institute.

Arch Ophthalmol. 1932;8(4):568-575. doi:10.1001/archopht.1932.00820170088007

During the last twenty years there have been two views of the development of the human cornea. Nussbaum1 supported the theory of Kölliker, that following the detachment of the lens vesicle the cells of the head mesoderm grew into the space between the ectoderm and the lens. This layer increased in thickness and then split into two portions, the anterior zone becoming the cornea, and the posterior layer forming the pupillary membrane and mesodermal portion of the iris. Descemet's mesothelium then appeared at a later stage and formed the posterior boundary layer of the cornea. As recently as 1928, Mann2 in "The Development of the Human Eye" supported this view. Figures 1 and 2 illustrate the chief steps in the corneal development according to this view.

In figure 1, the lens has separated entirely from the surface ectoderm and lies in the optic cup. The head mesoderm has

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