Cataracts develop frequently in young rats fed on a diet deficient in vitamin G. In addition to the opacities of the lens, other pathologic changes occur in the eyeballs and lids.
In the present unsatisfactory state of knowledge regarding vitamins, it is known that water-soluble vitamin B, such as is found in yeast, rice, wheat, fresh meats, green leaves, etc., is a complex vitamin and is made up of two or possibly three factors. One factor of this B complex is the vitamin known as B, F or B1; this is antineuritic, comparatively thermolabile and soluble in alcohol. The other well known factor is vitamin G or B2 ; this is pellagra preventive, comparatively thermostabile and almost insoluble in alcohol. A third factor, vitamin B3, is apparently necessary for the maintenance of growth.
Young rats deprived of vitamin G fail to gain in weight and, after a
O'BRIEN CS. EXPERIMENTAL CATARACT IN VITAMIN G DEFICIENCY. Arch Ophthalmol. 1932;8(6):880–887. doi:10.1001/archopht.1932.00820190100011