Uhlenhuth,1 in 1903, announced his discovery of the organ specificity of lens protein. Briefly summarized, organ specificity means that the chemical structure of an organ or tissue is the same in all species, and differs from the general tissue proteins so markedly that the organ specific substance is capable of acting as a foreign protein. Specifically, when lens extracts are injected into rabbits or other species, the animals respond by producing precipitins and complement-fixing bodies which react in the test tube with lens extracts from all vertebrate species. In our studies lens extracts have been found to fulfil the foregoing specification and to be organ specific except in the particular that whole lens extract did not act as an antigen in the homologous animal. It is the purpose of this paper, therefore, to describe our studies of this exception, and our experiments with whole lens and its fractions
BURKY EL, WOODS AC, WOODHALL MB. ORGAN SPECIFIC PROPERTIES AND ANTIGENIC POWER IN HOMOLOGOUS SPECIES OF ALPHA CRYSTALLIN. Arch Ophthalmol. 1933;9(3):446–449. doi:10.1001/archopht.1933.00830010462010
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