Before the time of A. von Hippel, who founded the so-called second tuberculin era in ophthalmology, tuberculins usually were used in large doses for the treatment of ophthalmic tuberculosis. Uhthoff (1891) gave 0.5 mg. of old tuberculin to children and 1 mg. to adults. Königshöfer and Maschke (1891), Schwaer (1891) and Cohn (1891) gave 0.75 mg. Diem (1906) gave from 1 to 3 mg., and Schaffranek (1909) gave 1 mg. Other ophthalmologists have administered even larger doses. In most of the cases, however, this mode of application of tuberculin did not bring about the anticipated success, but, on the contrary, proved to be injurious, as it produced anaphylactic symptoms which were peculiar to the nature of tuberculous diseases.
Since the time of von Hippel and his pupil Schieck, the views and principles of treating patients with tuberculous ophthalmic diseases with tuberculin have changed somewhat, because von Hippel's point of
NAKAMURA B. SPECIFIC TREATMENT OF OPHTHALMIC TUBERCULOSIS WITH A NEW TUBERCULOSIS VACCINE "AO". Arch Ophthalmol. 1933;10(2):161–165. doi:10.1001/archopht.1933.00830030009001
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