In a previous article by Smith and myself1 some facts concerning the reaction of solutions used in the eye were pointed out, and the advantages were indicated of using solutions with the following three properties: (1) stability of reaction under ordinary conditions of use, (2) the possible production of solutions of a known reaction within a certain range by simple changes in composition and (3) a bacteriostatic effect by the inclusion of an effective preservative.
It was found that these properties were obtained effectively by the combination of an acid buffer solution with a stock sodium carbonate solution. The addition of 1 cc. of the latter solution to 50 cc. of the former gave a solution with a ph of 7.6, which we called an alkaline buffer solution.
Since this article was published it has become apparent through our own use of drugs in these solutions and through