[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 18.206.175.155. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
March 1935

TOXIC AMBLYOPIA DUE TO TOBACCO AND ALCOHOL: TREATMENT WITH VASODILATORS ; A REPORT OF EIGHT CASES

Arch Ophthalmol. 1935;13(3):435-444. doi:10.1001/archopht.1935.00840030129008
Abstract

As early as 1896, de Schweinitz,1 in his classic work on the toxic amblyopias, commented on the action of strychnine, amyl nitrite and nitroglycerin on amblyopia arising from the use of tobacco. He shrewdly remarked that strychnine, when administered during the inflammatory stage of a lesion of nerve tissue, e. g., ordinary peripheral neuritis, usually aggravates the disorder but is beneficial in axial optic neuritis caused by tobacco poisoning. He suggested that this might be a therapeutic test proving that vascular change and not inflammation is the early underlying pathologic process in the optic nerve in simple tobacco amblyopia.

Somewhat later, Parsons,2 after making a careful study of the pathologic changes in the toxic amblyopias, reviewed the various hypotheses of the action of tobacco or nicotine on the retinal cells and synapses and discarded Fisher's theory that such action directly affects the cells. He cited Holden's3

×