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Article
May 1935

LOCAL QUININE THERAPY IN CASES OF INTERSTITIAL KERATITIS AND OLD CORNEAL OPACITIES

Arch Ophthalmol. 1935;13(5):829-832. doi:10.1001/archopht.1935.00840050107010
Abstract

In a paper read before the Chicago Ophthalmological Society on Nov. 19, 1934, I1 reported the methods and results of local quinine therapy in trachoma. The rationale of the quinine therapy is that quinine, besides being a bactericide and an astringent, is a protoplasmic poison which penetrates deeply into the tissues when applied locally to mucous membranes. Binz,2 Roth3 and others showed that it destroys leukocytes and lymphocytes in and out of blood vessels, and that its destructive effect on lymphocytes is particularly marked. As Cushny4 stated, quinine acts on the nutrition of almost all forms of protoplasm, causing first an augmentation of its activity, later depression and finally death. Experiments on animals and clinical trials in cases of trachoma showed that 2 per cent and 4 per cent quinine bisulphate ointment and a 10 per cent aqueous solution of quinine bisulphate can be applied locally

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