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September 1935


Author Affiliations

From the Department of Ophthalmology, Northwestern University Medical School.

Arch Ophthalmol. 1935;14(3):408-411. doi:10.1001/archopht.1935.00840090094004

For the past two years the literature, more especially that in German, has brought forth the study and evaluation of new anesthetics for local and subcutaneous use. During the first part of 1932 the Hoffmann-LaRoche Company sent me a quantity of larocaine for trial. During the progress of my study, various authors, to be cited later, have published articles concerning this anesthetic. Therefore, this paper will be presented as a confirmation and substantiation of previously published findings, together with additions which will make the American reader acquainted with the product.

Larocaine, a synthetic product, is the p-aminobenzoyl ester of 2,2-dimethyl-3-diethylamino-1-propanol. It is supplied in the form of a hydrochloride, a white crystalline powder soluble in water up to 50 per cent. Chemically, it is akin to procaine hydrochloride and tutocaine. It is stated that the lethal dose for the mouse is 0.3 Gm. per kilogram of body

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