Ruby in 1933 called attention to the fact that through developments in the lacquer industry there were available on the market products of nitrocellulose from which masses for embedding could be prepared that had certain advantages over the pyroxylin hitherto used for histologic purposes. According to Wilson, the viscosity of commercial brands of pyroxylin ranges from two hundred seconds to one-half second, as measured by the falling ball test. Ruby used nitrocellulose with a viscosity of one-half second manufactured by the Hercules Powder Company. Tissue that had remained in the nitrocellulose blocks for a year in his laboratory had shown no change in staining characteristics that could have been produced by the nitrocellulose.
In 1934 Davenport and Swank1 reported on the use of nitrocellulose of the same degree of low viscosity. They found that it was possible to obtain a firmer block with less shrinkage with this
Fry WE. NITROCELLULOSE OF LOW VISCOSITY USED AS AN EMBEDDING MEDIUM FOR EYES THAT ARE TO BE SECTIONED. Arch Ophthalmol. 1935;14(3):482–483. doi:10.1001/archopht.1935.00840090168014
Browse and subscribe to JAMA Network podcasts!
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: