When in 1915 Fuchs1 gave a classic description of a corneal lesion which he called "keratitis pustuliformis profunda," he left open only the question of the earliest symptoms of the disease and its etiology.
Concerning these two points Meller2 and Seefelder3 in the following years gave valuable additional information supported by the rapidly increasing general use of serologic tests.
Meller had the opportunity to observe the incipient symptoms of the corneal lesion in a patient who showed the fully developed picture in the other eye. He reached the conclusion that the keratitis is probably primary or at least coordinate with the severe hypopyon iritis. In Meller's and Seefelder's cases the Wassermann reaction of the blood was positive, and the course of the disease was favorably influenced by antisyphilitic treatment, resulting in useful visual acuity.
Other cases with similar therapeutic results were reported by A. Fuchs,4 Schneider,
KLIEN BA. ACUTE METASTATIC SYPHILITIC CORNEAL ABSCESS: A CLINICAL AND HISTOPATHOLOGIC STUDY. Arch Ophthalmol. 1935;14(4):612–617. doi:10.1001/archopht.1935.00840100096008
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