Lenticular changes have been produced in experimental animals in various ways. Foreign and toxic substances like naphthalene and thallium have been utilized for the production of experimental cataract. Changes in the lens have been observed in depancreatized dogs and in parathyroidectomized rats. In contrast to these more drastic modes of research, which involve a generalized intoxication of the experimental animal, there are available nutritional methods for the production of ocular lesions. Cataract has been produced in rats on a diet low in tryptophan, although this finding has not been uniformly obtained. Cataract has been obtained in young rats deprived of vitamin G. More recently, Mitchell and Dodge 1 reported changes in the lens tissue of rats subsisting on a ration containing a high proportion of lactose. The animals showed no other visible changes in the eye. Similar results have been obtained in our laboratory.
The ready production of lenticular opacities
YUDKIN AM, ARNOLD CH. CATARACTS PRODUCED IN ALBINO RATS ON A RATION CONTAINING A HIGH PROPORTION OF LACTOSE OR GALACTOSE. Arch Ophthalmol. 1935;14(6):960–966. doi:10.1001/archopht.1935.00840120098011
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