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Article
January 1936

EFFECT OF BACTERIAL LYSATE ON STAPHYLOCOCCIC KERATOCONJUNCTIVITIS IN RABBITS

Author Affiliations

PHILADELPHIA
From the Clinical Laboratory and the Ophthalmology Department of the Bryn Mawr Hospital.

Arch Ophthalmol. 1936;15(1):47-58. doi:10.1001/archopht.1936.00840130057006
Abstract

Our purpose in this experimental work was twofold: first, to determine the effect of bacterial lysate on staphylococcic keratoconjunctivitis in rabbits and, second, more important, if an effect was obtained, to investigate which portion of the lysate was responsible for it.1

The work was suggested by the results obtained in the use of bacterial lysate in the treatment of six patients with chronic staphylococcic blepharoconjunctivitis and one patient with a corneal ulcer in each eye.

REPORT OF CASES

Miss S. C. was first seen on May 3, 1933. The eyelids had been crusted for six months, and the conjunctiva had been red and injected. Treatment with various standard preparations had no effect. An autogenous bacterial lysate from Staphylococcus aureus (nonhemolytic) and Staphylococcus albus was prepared on May 11 and used in an ointment of hydrous wool fat and petrolatum continuously until June 21. An improvement in

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