The clinical recognition of retinoblastoma is so difficult that error occurs in nearly one third of all the cases in which the eye is removed for this disease ; therefore, any laboratory aid which distinguishes the real tumor from the pseudotumor should be of interest.
It has long been known that calcareous changes or deposits occur in retinoblastomas. In three of the seven cases of glioma described by Knapp1 in 1869, in his celebrated monograph on intra-ocular tumor, calcium bodies were shown in histologic sections. Much earlier than this, Charles Robin1 described calcareous degeneration in gliomas. These calcareous deposits appear in histologic sections as irregular bodies or masses, from 30 microns to 1 mm. or more in size, which stain with hematoxylin and are usually observed in association with other degenerative changes in the tumor. According to Collins,2 they are formed by the breaking down of a number
PFEIFFER RL. ROENTGENOGRAPHIC DIAGNOSIS OF RETINOBLASTOMA. Arch Ophthalmol. 1936;15(5):811–821. doi:10.1001/archopht.1936.00840170023002
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