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Article
July 1936

RELATION BETWEEN BLUE SCLERAS AND HYPERPARATHYROIDISM

Author Affiliations

NEWARK, N. J.

Arch Ophthalmol. 1936;16(1):8-35. doi:10.1001/archopht.1936.00840190018003
Abstract

The clinical entity consisting of blue scleras, osteoporosis with spontaneous fractures and deafness and the dominant hereditary transmission of the syndrome have long been known to ophthalmologists and pediatricians. The association of blue scleras with fragilitas ossium was noted by Ekman (1788), Lobstein (1833) and von Ammon. Van der Hoeve and de Kleyn1 and Bronson2 independently included hereditary deafness (which, according to some observers, may develop only after the age of 20) as a part of the entity. German authors commonly refer to this symptom complex as the van der Hoeve and de Kleyn syndrome, while in the English literature there is a tendency to link the entity with the name of Lobstein.

It is not pertinent to the purpose of this article to delve into the early historical facts or to decide to which authorities credit should be given for advancement in the knowledge of

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