Primary tumor of the optic nerve is not common, although in the literature of the past sixty-four years about 300 cases of tumor of the optic nerve have been reported. Four have been observed at the Massachusetts' Eye and Ear Infirmary in Boston in thirty-six years, and one, at the Wills Hospital in Philadelphia in twelve years. Hudson1 found that this type of tumor was more common in females than in males and that 75 per cent of the patients were in the first decade of life, which led some authors to suggest that the neoplasm is congenital.
The tumor may spread from the intra-orbital to the intracranial portion of the optic nerve through the optic foramen or from the intracranial to the intra-orbital portion of the nerve. In possibly the majority of the cases reported the neoplasm has occurred in the intra-orbital portion of the
MEHNEY GH. PRIMARY TUMOR OF THE OPTIC NERVE: REPORT OF THREE CASES. Arch Ophthalmol. 1936;16(1):95–102. doi:10.1001/archopht.1936.00840190105013
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