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Article
August 1936

BIOCHEMISTRY OF THE LENS: VIII. A NEW PROOF OF THE PRESENCE OF VITAMIN C IN THE CRYSTALLINE LENS

Author Affiliations

CHICAGO
Ward fellow in ophthalmology.; From the Department of Ophthalmology and the Department of Physiological Chemistry, Northwestern University.

Arch Ophthalmol. 1936;16(2):248-251. doi:10.1001/archopht.1936.00840200086008
Abstract

In previous reports by one of us (J. B.1) the literature concerning vitamin C in the eye was reviewed. It was pointed out that in the normal eye the lens and aqueous are very rich in this substance, that in the cataractous lens the amount of vitamin C is diminished or entirely absent and that the aqueous of an aphakic eye contains only a slight amount of this substance. Experiments were performed which showed a definite reduction in the vitamin C content of the blood in persons with cataract. The crystalline lens was shown to possess a marked preserving action on solutions of vitamin C, whereby oxidation in air is greatly diminished. Furthermore, vitamin C is absorbed from the conjunctival sac into the anterior chamber. Presumably this takes place through the cornea.

In these experiments the amount of cevitamic acid was determined by titration with sodium 2,6-di-chlorobenzenone-indophenol.

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