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Article
August 1936

CORNEAL DYSTROPHY IN THREE GENERATIONSWITH A GENEALOGICAL CHART

Arch Ophthalmol. 1936;16(2):257-270. doi:10.1001/archopht.1936.00840200095011
Abstract

In 1890 Groenouw1 described a slowly progressive degeneration of the cornea consisting of numerous small rounded grayish nonconfluent opacities in an otherwise clear cornea. In 1898 he described the anatomic findings, stating that the condition is a subepithelial degeneration, and in 1917 he reported a series of cases in three generations of a family. Finally, in 1933, he read a paper on a nodular type of corneal dystrophy transmitted through four generations and noted that he had personally examined all four generations of the same family.

Since Groenouw's first description of this disease there have appeared in the literature from time to time reports of other conditions of a similar nature but described under a variety of names, such as corneal nodular opacity, corneal nodular degeneration, familial corneal degeneration, nodular keratitis, lattice-shaped keratitis, hereditary ocular degeneration and reticular keratitis. In reviewing the literature one is impressed with the

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