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Article
September 1936

CATARACT FOLLOWING DI-NITROPHENOL TREATMENT FOR OBESITY

Author Affiliations

SAN FRANCISCO
From the Department of Ophthalmology, the University of California Medical School.

Arch Ophthalmol. 1936;16(3):447-461. doi:10.1001/archopht.1936.00840210121009
Abstract

An excellent review of the subject of di-nitrophenol in general was given in a report by the Council on Pharmacy and Chemistry of the American Medical Association,1 from which I shall quote freely.

The actions of certain nitro derivatives of phenol and naphthol as accelerators of metabolism have been studied for the past fifty years. Cazeneuve and Lepine2 in 1885 described the increase in the metabolism of dogs given di-nitronaphthol. A few years later Gibbs and Reichert3 reported similar observations with the use of di-nitrophenol.

During the war many cases of di-nitrophenol poisoning were observed among French munition workers. The poisoning, which was often severe and sometimes fatal, occurred so frequently that special pharmacologic study was instituted. The findings were reported on by Magne, Mayer and Plantefol4 in France and by Perkins5 in America.

In 1933 Tainter and Cutting1 and their coinvestigators, proceeding independently,

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