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March 1937

Fish Lens Protein and CataractII. CHEMICAL STUDIES

Arch Ophthalmol. 1937;17(3):508-512. doi:10.1001/archopht.1937.00850030122010

The clinical evidence which was brought forward in the first paper of this series1 indicates that fish lens protein is a therapeutic agent for the nonsurgical treatment of incipient cataract. The problem for the past few years has been the isolation of that portion of fish lens protein which is remedial.

Many studies made on the human lens have fairly well established the fact that it consists essentially of an insoluble portion, which is possibly

well called an albuminoid, and three water-soluble, heat-coagulable proteins, which have been named alpha, beta, and gamma crystallins. Various investigators have claimed that these crystallins are albumins, globulins, pseudoglobulins or euglobulins. However, regardless of into what arbitrary classification these may be placed, the fact remains that in the human lens there are but three water-soluble substances which have been identified as proteins.

Beginning with the original works of Laptschimski and the classic researches

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