The ophthalmoscopic appearance of drusen, or "colloid" excrescences on the lamina vitrea, is well known. The changes are seen in elderly persons as numerous bright, sharply circumscribed points with slightly pigmented margins and are usually in the macular zone or around the papilla. In some cases the discrete points become confluent and rather large. The majority of patients with this condition have no visual disturbances, but when the dots are very numerous and fused, the condition can result in diminution of the visual acuity by pressure on the rods and cones that causes their atrophy. Such senile changes early attracted the attention of the pathologists, and H. Müller1 in 1855 carefully studied them. He found that they were almost constant in persons over 60 years of age, very frequent in persons over 45 and not rare in younger persons. Histologically, they were observed to be most
RONES B. FORMATION OF DRUSEN OF THE LAMINA VITREA. Arch Ophthalmol. 1937;18(3):388–402. doi:10.1001/archopht.1937.00850090056007
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