A method of rapidly producing and increasing the antibody titer of the blood by the intravenous administration of typhoid H antigen has been recently described. The beneficial effect of an increased intra-ocular concentration of H antibodies on intra-ocular inflammation has likewise been reported.1 Briefly, the titer of the blood may rise to 1: 100+ in from forty-eight to fifty hours after an intravenous injection of a solution of typhoid H antigen containing 15,000,000 organisms. At this time the titer of the aqueous is usually not measurable. After paracentesis of the anterior chamber, the titer rises to 1:6 or 1: 8. This concentration was found to have an inhibiting power on the production of experimental iritis in sensitized rabbits. Higher concentrations could be obtained by further tappings, with consequently greater inhibiting power. This method was applied clinically to patients with various types of uveal inflammation, with
ALBERT L. BROWN. USE OF TYPHOID H ANTIGEN BEFORE INTRA-OCULAR OPERATIONS. Arch Ophthalmol. 1938;19(2):181–183. doi:10.1001/archopht.1938.00850140023002
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