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Article
February 1938

EXPERIMENTAL STUDIES OF OCULAR TUBERCULOSIS: III. RELATION OF CUTANEOUS SENSITIVITY TO OCULAR SENSITIVITY IN THE NORMAL RABBIT INFECTED BY INJECTION OF TUBERCLE BACILLI INTO THE ANTERIOR CHAMBER

Author Affiliations

BALTIMORE
From the Wilmer Ophthalmological Institute of the Johns Hopkins University and Hospital.

Arch Ophthalmol. 1938;19(2):245-250. doi:10.1001/archopht.1938.00850140087010
Abstract

In the first study of this series1 it was found that in rabbits systemically inoculated with human tubercle bacilli the eye participated in the general body sensitivity developing after inoculation. Ocular sensitivity developed synchronously with cutaneous sensitivity, and, with minor variations, ran a fairly parallel course, the cutaneous sensitivity affording a reasonably accurate index of the sensitivity of the undiseased eyes. In the second study it was pointed out that when the normal rabbit was inoculated with tubercle bacilli in the anterior chamber and the primary tuberculous focus lay in the eye, ocular sensitivity began to develop about the second week after inoculation and reached its height in about four weeks. The eyes showed a slowly progressive tuberculous inflammation during the first few weeks, which became acute, with caseation and necrosis, as the ocular sensitivity developed to maximum. Active tuberculous inflammation and ocular sensitivity persisted steadily up

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