[Skip to Navigation]
May 1938


Author Affiliations

From the Department of Ophthalmology and the Department of Fever Therapy of the University of Cincinnati College of Medicine and the Cincinnati General Hospital. This paper is a part of a dissertation submitted to the Graduate School of the university in partial fulfilment of the requirements for the degree of Master of Science. Forty-two of the cases were reported at the First International Conference on Fever Therapy, New York, March 30, 1937. The historical review and summary of physiologic and pathologic changes occurring during and after fever therapy have been omitted as they are not of direct ophthalmologic interest.

Arch Ophthalmol. 1938;19(5):769-796. doi:10.1001/archopht.1938.00850170119010

The empiric therapeutic use of artificially induced fever had its origin in antiquity. Only in the last two decades has there been notable progress in the rational or scientific use of fever in combating disease.

The present activity in the field of fever therapy began in 1918, when Wagner-Jauregg published his excellent work on the treatment of dementia paralytica with induced malaria. Nonspecific protein therapy had been introduced only a short time prior to this. In the past six years the production of hyperpyrexia by physical means has been widely studied.

Innumerable diseases of widely divergent character have been treated with fever therapy with equally varying results. Some interest has already been exhibited in this form of therapy by ophthalmologists, particularly in the treatment of syphilitic ocular diseases and gonorrheal ophthalmia and, to a lesser extent, in the treatment of corneal ulcers and iritis of nonspecific origin. After consideration of

Add or change institution