In the literature on the mechanism of glaucoma one finds that all the theories proposed have as their basis of explanation a disturbance or change in some particular structure of the eye. These theories actually fail to explain the mechanism of chronic simple glaucoma. In the observation of patients with this disease the impression is inescapable that in its clinical aspects chronic simple glaucoma presents striking analogies to such diseases as essential arterial hypertension and diabetes. The common denominator of these diseases is, as I shall show later, a disturbance in the regulation of physiologic function. On the basis of these analogies it seemed logical to attempt to explain the mechanism of chronic simple glaucoma as primarily a disturbance in the regulation of the normal intraocular pressure. It is the purpose of this communication to present the new concept. In the following discussion I shall, first, review briefly the
ELWYN H. PATHOGENESIS OF CHRONIC SIMPLE GLAUCOMAA NEW CONCEPT OF THE MAINTENANCE OF THE NORMAL INTRAOCULAR PRESSURE. Arch Ophthalmol. 1938;19(6):986–1008. doi:10.1001/archopht.1938.00850180138015
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