Herpes zoster of the eyes and forehead and sometimes of the side of the nose is one of the most stubborn diseases with which the ophthalmologist has to deal. The pain is often excruciating and sometimes cannot be relieved except by the administration of large doses of morphine.
For many years it has been known that when herpes occurred along the distribution of the fifth cranial nerve the eye of the side affected became involved. The sensory nerve fibers that supply the iris and some other parts of the eyeball are branches of the nasociliary nerve, which also supply the cornea ; sensory branches of the fifth nerve also supply the eyelids, the conjunctiva, the caruncle and the lacrimal sac. Since herpes zoster follows the course of the fifth nerve and its numerous branches, one can see how the vesicles can be so widely distributed on the side of
Walker JR, Walker BF. A SPECIFIC TREATMENT FOR HERPES ZOSTER. Arch Ophthalmol. 1938;20(2):304–306. doi:10.1001/archopht.1938.00850200142010
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