The condition which bears Marfan's name is characterized by the following symptoms: lack of subcutaneous fat, poorly developed musculature, elongated extremities and curvature of the spine. In approximately half of the cases the following conditions are also found: congenital cardiac disease, congenitally dislocated lenses, miosis and high myopia. The condition occurs with equal frequency in both sexes and usually is not recognized until the third or the fourth year; often it is not diagnosed until adult life has been reached. It is a hereditary condition which can be transmitted by males and females alike and is considered by most authorities to be transmitted by changes in a varying number of chromosomes. If only chromosomes concerned with mesodermal development are involved, the ocular symptoms are absent (congenital mesodermal dystrophy) ; if chromosomes concerned with ectodermal development are also affected, the suspensory ligament of the lens and sometimes the dilator
LAVAL J. BILATERAL CONGENITAL ECTOPIA LENTIS WITH ARACHNODACTYLY (MARFAN'S SYNDROME). Arch Ophthalmol. 1938;20(3):371–374. doi:10.1001/archopht.1938.00850210027003
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