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September 1938

Citric Acid Studies Referring to the Eye.

Arch Ophthalmol. 1938;20(3):530. doi:10.1001/archopht.1938.00850210186022

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This monograph, published as the fourteenth supplement of the Acta Ophthalmologia, is concerned chiefly with the occurrence of citric acid in the intraocular fluids. It begins with a discussion of the application and limitations of the Thunberg enzymatic method for the determination of citric acid. The different qualitative tests which confirm the presence of the acid in ocular fluids and tissues are reported. The quantity of citrate in the intraocular fluids and serums of various mammals, birds and fish, of bovine fetuses and also of patients suffering from different ocular diseases is recorded. It also deals with the relation of blood, tears, corneal permeability and retinal dehydrogenases to the metabolism of citric acid.

Citric acid is found in intraocular fluid in all mammals, birds and fish, although the amount in birds is higher than in other animals. Unlike dextrose, citric acid is evenly distributed throughout the vitreous

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