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Article
October 1938

NATURE OF THE FILTRABLE AGENT OF TRACHOMA

Author Affiliations

NEW YORK; Medical Director in Charge of Trachoma Activities, Indian Service ALBUQUERQUE, N. MEX.
From the Department of Ophthalmology, College of Physicians and Surgeons, Columbia University, and the Institute of Ophthalmology, Presbyterian Hospital, in cooperation with the Division of Health, Office of Indian Affairs, Department of the Interior, Washington, D. C.

Arch Ophthalmol. 1938;20(4):569-584. doi:10.1001/archopht.1938.00850220041002
Abstract

It is now generally agreed that none of the bacteria which have been found on the trachomatous conjunctiva are concerned etiologically in the disease. In 1912 Nicolle, Blaizot and Cuénod1 concluded, on the basis of two filtration experiments in which they had employed modified Berkefeld V filters, that the agent of trachoma was filtrable. In the first experiment a bacteria-free filtrate of trachomatous material produced a disease typical of experimental trachoma in a Macacus inuus (Barbary ape) which was proved to be trachoma by transfer to a blind human eye. In the second experiment a bacteria-free filtrate proved infectious for a chimpanzee.

Confirmation of the filtrability of the agent of trachoma has come from the experiments of Thygeson and Proctor2 with baboons, Thygeson, Proctor and Richards3 with a human volunteer and Julianelle, Morris and Harrison4 with Macacus rhesus monkeys. These investi- gators have found

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