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October 1938


Author Affiliations


Arch Ophthalmol. 1938;20(4):585-596. doi:10.1001/archopht.1938.00850220057003

Myerson and Thau1 were the first to propose that benzedrine sulfate might be a useful adjunct to atropine in preparation of the eyes for refraction. The effects of benzedrine sulfate combined with homatropine hydrobromide were investigated by Beach and McAdams,2 who concluded that the depth of cycloplegia obtained equaled that obtained by the usual method of administering homatropine but was of distinctly shorter duration. Further study of this subject was made by Powell and Hyde,3 who in their conclusions expressed entire agreement with Beach and McAdams.

The purpose of this study was to investigate cycloplegia produced with homatropine and benzedrine4 from the point of view of its depth and, further, to determine what part each drug contributes to the combined action.

Depth of cycloplegia is a problem which cannot be approached without an accepted method for its estimation. This is provided by the