Leduc in 1900 was the first to describe methods of therapeutic ionization and in 1903 he published the first report on the application of zinc ions in the treatment of rodent ulcer. In 1904 he used quinine in the treatment of an acute attack of tic, claiming a favorable result.
Ramsden in 1908 reported a case of ophthalmia neonatorum in which cure was effected in two days with ionization.
Traquair1 in 1911 treated corneal ulcers with zinc iontophoresis. His best results were achieved in cases of moderately severe involvement and also in those cases in the advanced stage in which the condition of the cornea contraindicated cauterization. Scar formation was less extensive than with the use of cautery. The application of a small electrode was found most advantageously effective, a current of 0.5 milliamperes being used for one and a half minutes.
Birkhäuser2 in 1921 experimented
SEECH SG, COOPER WL. EXPERIMENTAL IONTOPHORESIS OF RABBITS' CORNEAS: REPORT OF TWO CASES OF CORNEAL DYSTROPHY WITH TREATMENT BY IONIC MEDICATION. Arch Ophthalmol. 1938;20(4):624–640. doi:10.1001/archopht.1938.00850220096006
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