In healthy dogs and monkeys (macaques) persistent elevation of the systolic and the diastolic pressure, with or without a decrease of renal excretory function, followed permanent partial constriction of the main renal arteries.1
The eyes of these hypertensive animals have been studied during a period of more than five years. A preliminary report2 and an interim report3 have been made.
These dogs exhibited two definite types of hypertension: a benign phase, without a decrease of renal excretory function, and an acute malignant phase, with very high blood pressure and severe damage of the renal excretory function. These two phases correspond to the benign and malignant phases of essential hypertension in man. The acute malignant phase of hypertension occurred, or was produced, in dogs already hypertensive, owing to constriction of the main renal arteries when the arteries were reconstricted to a great degree, or in healthy dogs in
KEYES JEL, GOLDBLATT H. EXPERIMENTAL HYPERTENSION: VIII. VASCULAR CHANGES IN THE EYES. Arch Ophthalmol. 1938;20(5):812–828. doi:10.1001/archopht.1938.00850230118009
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