In February 1938 Dr. Fred Loe, of Rosebud, S. D., notified us of his successful treatment of trachoma in Indian subjects with sulfanilamide, the details of which he has recently published.1 Favorable results were also reported by Lian.2
After obtaining marked improvement with this treatment in certain isolated cases and rapid cure in 2 cases of experimental trachoma in baboons, we decided to test the drug on a series of persons with previously untreated active follicular trachoma in whom corneal progress could be followed by means of the slit lamp and the corneal microscope.
Accordingly, we selected 14 Apache Indian children with active follicular trachoma, 12 to be treated and 2 to be kept untreated as controls. All children had pannus and exhibited corneal activity, as evidenced by dilated pannus vessels, subepithelial infiltrates and fluorescein-staining punctate epithelial lesions. Typical epithelial cell inclusions, characteristic of active trachoma, were demonstrated
RICHARDS P, FORSTER WG, THYGESON P. TREATMENT OF TRACHOMA WITH SULFANILAMIDE. Arch Ophthalmol. 1939;21(4):577–580. doi:https://doi.org/10.1001/archopht.1939.00860040015001
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