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April 1939


Author Affiliations

Medical Director in Charge of Trachoma Activities, Indian Service ALBUQUERQUE, N. M.; Special Physician, Indian Service FORT APACHE, ARIZ.; NEW YORK
From the Division of Health, Office of Indian Affairs, Washington, D. C., in cooperation with the Department of Ophthalmology, College of Physicians and Surgeons, Columbia University, and the Institute of Ophthalmology, Presbyterian Hospital, New York.

Arch Ophthalmol. 1939;21(4):577-580. doi:10.1001/archopht.1939.00860040015001

In February 1938 Dr. Fred Loe, of Rosebud, S. D., notified us of his successful treatment of trachoma in Indian subjects with sulfanilamide, the details of which he has recently published.1 Favorable results were also reported by Lian.2

After obtaining marked improvement with this treatment in certain isolated cases and rapid cure in 2 cases of experimental trachoma in baboons, we decided to test the drug on a series of persons with previously untreated active follicular trachoma in whom corneal progress could be followed by means of the slit lamp and the corneal microscope.

Accordingly, we selected 14 Apache Indian children with active follicular trachoma, 12 to be treated and 2 to be kept untreated as controls. All children had pannus and exhibited corneal activity, as evidenced by dilated pannus vessels, subepithelial infiltrates and fluorescein-staining punctate epithelial lesions. Typical epithelial cell inclusions, characteristic of active trachoma, were demonstrated