Toxic amblyopia, with centrocecal scotomas and relatively larger scotomas for red and green, and commonly with peripheral neuritis and hypochlorhydria, appears to be generally accepted to be associated with dietary deficiencies of the vitamin B complex. The more rapid clinical improvement following the use of brewers' yeast or other forms of vitamin B1 appears generally to be sufficiently satisfactory to cause it to be considered a routine therapeutic agent.
Admitting the multiple deficiencies from which these patients suffer, I desired to ascertain which of the vitamin B factors, if any, singly would give results most approaching the clinical improvement following the use of brewers' yeast. Thiamin chloride (B1) and nicotinic acid appeared to be the most probable factors in the B complex and were therefore used.
—The first patient seen had centrocecal scotomas for red and green in each eye, a small scotoma in the left eye
JOHNSON LV. ALCOHOL-TOBACCO (TOXIC) AMBLYOPIA TREATED WITH THIAMIN CHLORIDE. Arch Ophthalmol. 1939;21(4):602–603. doi:https://doi.org/10.1001/archopht.1939.00860040040004
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