Endothelial dystrophy, or cornea guttata, is generally considered at the present time to be a degenerative senile or presenile condition which may progress and later predispose to epithelial changes, notably the epithelial dystrophy of Fuchs. This concept, which is the only one held by all English and American contributors to the subject, is based on the work of Vogt and of Graves. Even the recent textbook by Duke-Elder1 shares this point of view and, like other texts, in an apparently complete discussion omits any reference to the original describers, first Koeppe and later Staehli, and fails to mention several case reports which point to a congenital basis for some of these cases. Because of this misconception, the condition in the cases reported here was at first unclassified and, in fact, considered hitherto undescribed. It was only after a fairly complete review of the literature that its nature was understood
THEODORE FH. CONGENITAL TYPE OF ENDOTHELIAL DYSTROPHY. Arch Ophthalmol. 1939;21(4):626–638. doi:10.1001/archopht.1939.00860040064006
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.