Trachoma, a protean disease of the conjunctiva and cornea, has been known since the time of Hippocrates. Hirschberg1 in 1904 stated that entire libraries have been written concerning the disease. Scientific experiments have been carried on for over a century, but trachoma still remains a dark chapter in ophthalmology.
Opinions as to the etiologic factors, the pathologic process and clinical picture of trachoma have been so contradictory that it is impossible to believe all that is written concerning the disease. Before the discovery of the inclusion bodies by Halberstädter and Prowazek2 many micro-organisms found in the conjunctiva were suspected of being causative agents. With this momentous discovery, new impetus was gained and many publications appeared. In 1928 Noguchi3 described a small rodshaped micro-organism which he named Bacterium granulosis ; this organism caused a follicular conjunctivitis in monkeys which was thought to be trachoma ; however, it did not cause
BRALEY AE. THE RICKETTSIA QUESTION IN TRACHOMA: I. MICROSCOPIC OBSERVATIONS ON THE VIRUS. Arch Ophthalmol. 1939;21(5):735–740. doi:10.1001/archopht.1939.00860050019002
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