Previous attempts to produce a standardized corneal ulcer in the rabbit have been unsatisfactory. Bach1 in 1894 was the first to attempt the production of a corneal ulcer for the purpose of evaluating specific treatment. He was not able to obtain uniformity, nor was Key2 or Bursuk.3 Brown and Pugh4 finally succeeded in producing a fairly satisfactory ulcer by using a strain of staphylococcus which they found only after many trials. Most strains gave either too much inflammatory reaction or none at all. No mention is made in their paper of the production of hemolysin or pigment by their strain.
Strumia and Scarlett5 in 1936 succeeded in obtaining a consistent keratoconjunctivitis for their study of the therapeutic effect of specific bacteriophage. They were able to get consistent infection only by giving intradermal injections of heat-killed staphylococci for three days previous to the injection of live organisms
McDONALD R, PETTIT H. THE PRODUCTION OF CORNEAL ULCERS IN THE RABBIT. Arch Ophthalmol. 1939;21(5):817–822. doi:https://doi.org/10.1001/archopht.1939.00860050101007
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