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May 1939


Arch Ophthalmol. 1939;21(5):828-832. doi:10.1001/archopht.1939.00860050112009

The usual manifestations of serum sickness are common and are universally recognized. Even relapses, which occur from time to time after free intervals, are well known. Focal reactions in the course of serum sickness, however, are much rarer. The most common type is paralysis due to neurologic disturbances, of which about 100 cases have been reported.1 Ocular involvement in serum sickness has apparently been the subject of only three contributions, two of which deal with optic neuritis and the third with edema of the retina.2 The first was that of Mason,3 who in 1922 described 3 cases in which measurable blurring of the optic disks developed during serum sickness. Two of the patients had received antipneumococcus serum, while the third had been given antimeningococcus serum. A gradual return to normal occurred. In another report Brown4 in 1925 observed that of 75 persons receiving diphtheria antitoxin, a

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