Approximately thirty years have elapsed since Elschnig1 first proposed the anaphylactic theory of sympathetic ophthalmia. During this time a considerable amount of evidence has accumulated, some of which indicates that allergy to uveal pigment may play some as yet undetermined part in the pathogenesis of this disease. Elschnig's work has been strongly supported abroad by several workers and in the United States notably by Woods,2 who has elaborated on the theory.
In the main, the evidence presented in support of Elschnig's theory consists in the demonstration that uveal pigment possesses antigenic properties in the host; that it is organ specific, and that it materially lacks species specificity. The demonstration of these properties was attempted by various methods, among which the complement fixation reaction and the intracutaneous pigment test are of most value. Of these two, the intracutaneous test is easier to perform and interpret. This test was originally
LUCIC H. SENSITIZATION OF RABBITS TO UVEAL TISSUE BY THE SYNERGIC ACTION OF STAPHYLOTOXIN. Arch Ophthalmol. 1939;22(3):359–369. doi:10.1001/archopht.1939.00860090025002
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