Sulfanilamide (paraaminobenzenesulfonamide) has been used extensively for systemic infections of various types and has been especially valuable when streptococci, pneumococci and gonococci were found. Prior to 1936 there was no mention of sulfanilamide in the ophthalmic literature, but recently numerous papers have appeared relating to this drug. Reports on the value of sulfanilamide in ocular infections have been made by L. J. and R. F. Fernandez,1 Rambo,2 Mullen and others. Engelfried3 reported that after the oral administration of sulfanilamide to rabbits the drug was found to be widely diffused throughout the body. Rambo found sulfanilamide in the aqueous, lens and vitreous of rabbits' eyes ; he reported the beneficial effect of the drug when cultures of hemolytic streptococci were injected into the vitreous and aqueous of rabbits' eyes. However, a search of the available literature revealed no reports on the determination of sulfanilamide in the aqueous and vitreous
MENGEL WG. DETERMINATION OF SULFANILAMIDE IN AQUEOUS AND VITREOUS AFTER CONJUNCTIVAL AND ORAL ADMINISTRATION. Arch Ophthalmol. 1939;22(3):406–409. doi:10.1001/archopht.1939.00860090072009
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